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The Benefits of Bayesian Dosing

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“[Aminoglycoside Bayesian dose individualization] is a well-accepted practice… [Further studies] may not be feasible for ethical reasons.” – Ho et al.

Bayesian dosing has been shown to have such significant benefits that some leading researchers believe that further clinical trials may be unethical, due to the control arm being required to receive substandard treatment.

DoseMe uses Bayesian dosing to calculate a precise dose to achieve your clinical target. Studies have shown that this results in significant and substantial improvements to mortality, risk, and patient outcomes. To find out more, take a look at what other hospitals have achieved with Bayesian dosing.

Enhance Outcomes

The following papers are just some of the randomised clinical trials that show the patient benefits of dose-individualisation:

  1. Increased survival for childhood leukaemia patients.
  2. Improved survival for septic patients.
  3. Increased patients in therapeutic range (chemotherapy).
  4. Increased proportion of patients in therapeutic range:
  5. Decreased time to therapeutic stabilisation.
  6. Shortened febrile periods:

Reduce Adverse Events

Dose-individualisation reduces adverse events. The following RCTs demonstrate some of these benefits:

  1. Reduced risk of toxic drug levels.
  2. Reduction in bleeding events.1
  3. Reduction in bruising events.1
  4. Halve side-effects for chemotherapy patients.
  5. Decreased discontinuation due to adverse events.
  6. Decreased nephrotoxicity:

Reduce Costs

Improving patient outcomes and reducing adverse events is highly cost-effective. The studies below quantify the cost-benefits of individualised dosing:

  1. Cost-benefit ratio of between 4:1 and 52:1. (Review).
  2. Save $2,500 (USD, 2012) per patient.
  3. Substantial overall savings due to lowered mortality.
  4. Reduce hospital stay length by more than 6 days.
  5. 4.6 day reduction in hospital stay length.
  6. Halve the number of assays required.

DoseMe Platform

Discover how simple DoseMe is to use, see what drug packages are available and find out more about our licenses here.

Take a closer look

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Schedule your one-on-one demonstration below. You can also phone us on +61 7 3151 3033 or email hello@doseme.com.au.

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